Dr Loke Wai Mun Miss Claudine Loong Dr Loke Wai Mun Dr Loke Wai Mun Miss Claudine Loong Dr Loke Wai Mun Dr Loke Wai Mun is a lecturer at the School of Chemical & Life Sciences, Nanyang Polytechnic (NYP) Singapore and an adjunct lecturer at the School of Food & Human Nutrition, Newcastle University Singapore. Prior to NYP, he worked as a post-doctoral research fellow at the Medicine Department, National University of Singapore after obtaining his PhD with merit (Chemistry & Pharmacology) from the University of Western Australia, Perth. Dr Loke's research interests include: nutritional, pharmacological and therapeutic effects of dietary polyphenols and phytosterols with relevance to metabolic syndrome and cardiovascular diseases. clinical manifestations and associated molecular events in relations to dietary intervention. Selected Publications: Loke WM, Proudfoot JM, Stewart S, McKinley AJ, Needs PW, Kroon PA, Hodgson JM, Croft KD. Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: Lack of association between antioxidant and lipoxygenase inhibitory activity. Biochem. Pharmacol. 2008;75:1045-1053. Loke WM, Proudfoot JM, McKinley AJ, Needs PW, Kroon PA, Hodgson JM, Croft KD. Quercetin and its in vivo metabolites inhibit neutrophil - mediated LDL oxidation. J. Agri. Food Chem. 2008; 56 3609–3615. Loke WM, Hodgson JM, Proudfoot JM, McKinley AJ, Puddey IB, Croft KD. Pure dietary flavonoids, quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy human volunteers. Am. J. Clin. Nutr. 2008; 88: 1018-1025. Loke WM, Hodgson JM, Proudfoot JM, McKinley AJ, Puddey IB, Croft KD. Reply to JO Lundberg. Am. J. Clin. Nutr. 2009; 89: 652-653. Proudfoot JM, Barden AE, Loke WM, Croft KD, Puddey IB, Mori TA. HDL is the major lipoprotein carrier of plasma F2-isoprostanes. J. Lipid Res. 2009;50:716-722. Loke WM, Hodgson JM, Croft KD. The Biochemistry Behind the Potential Cardiovascular Protection by Dietary Flavonoids. In: Fraga CG, ed. Plant Phenolics and Human Health: Biochemistry, Nutrition and Pharmacology: John Wiley and Sons; 2009. Loke WM, Jenner AM, Proudfoot JM, McKinley AJ, Hodgson JM, Halliwell B, Croft KD. A Metabolite Profiling Approach to Identify Biomarkers of Flavonoid Intake in Humans. J. Nutr. 2009;139:2309-2314. Loke WM, Proudfoot JM, Hodgson JM, McKinley AJ, Hime N, Magat M, Stocker R, Croft KD. Specific Dietary Polyphenols Attenuate Atherosclerosis in Apolipoprotein E-Knockout Mice by Alleviating Inflammation and Endothelial Dysfunction. Arterioscler. Thromb. Vasc. Biol. 2010;30:749-757. Seet RCS, Lee CYJ, Loke WM, Huang SH, Looi WF, Chew SE, Quek AM, Lim EC, Halliwell B. Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute vs chronic oxidative stress? Free Radical Med. Biol. 2011; 50:1787-1793. Loke WM, Lam Mok Sing K, Chong WL, Chew SE, Quek AML, Lim ECH, Seet RCS. Products of 5-Lipoxygenases and myeloperoxidase activities are increased in young male cigarette smokers. Free Radical Res. 2012; 46:1230-1237. Seet RCS, Loke WM, Khoo CM, Chew SE, Chong WL, Quek AML, Lim ECH, Halliwell B. Acute effects of cigarette smoking on insulin resistance and arterial stiffness in young adults. Atherosclerosis. 2012; 224:195-200. Loke WM, Chow AY, Lam Mok Sing K, Lee CYJ, Halliwell B, Lim ECH, Quek AML, Ooi EE, Seet RCS. Augmentation of 5-Lipoxygenases activity and expression during dengue stereotype-2 infection. Virol. J. 2013; 10:322-328. Loke WM, Lam Mok Sing K, Lee CYJ, Chong WL, Chew SE, Huang H, Looi WF, Quek AML, Lim ECH, Seet RCS. Cyclooxygenase-1 mediated platelet reactivity in young smokers. Clin. Appl. Thromb. Hemost. 2014; 20:371-377. Ng M., Lee CYJ., Loke WM, Yeo L, Quek A, Lim EC, ... & Seet RC. Does influenza A infection increase oxidative damage?. Antioxidants & redox signaling 2014;21:1025-1031. Tsen YT, Siew J, Lau EKL, Roslee FA, Chan HM & Loke WM. Cow's milk as a dietary source of equol and phenolic antioxidants: Differential distribution in the milk aqueous and lipid fractions. Dairy Sci. Tech. 2014;94:625-632. Tsen YT & Loke WM. Differential Antioxidant & Antiinflammatory Activities of Daidzein & Equol. Malaysian Journal of Nutrition. 2015; 21:S148-S149. Loke WM, Tay ME, Tsen YT & Chu G. Nutrient Deficiency Risk Assessment of Free-Living Older Adults in Singapore. Malaysian Journal of Nutrition. 2015; 21:S161-162. Tsen YT, Tan XY, Tan YM, Yan BY & Loke WM. Bioavailability and intestinal transformation exert profound effects on anti-inflammatory and antioxidant activities of isoflavones such as daidzein. Journal of Medicinal Food. 2016; accepted for publication. Tay ME, Ong SH, Ho XL, Tsen YT, Chu G, Loong C, Khaw R, Lee MKJ & Loke WM. Nutrient Deficiency Risk Assessment of Free-Living Older Adults in Singapore. Journal of Aging Research and Clinical Practise. 2016; accepted for publication. Awards / Grants SPRING SINGAPORE Innovation & Capability voucher for Superlative Foods, 2016 SPRING SINGAPORE Innovation & Capability voucher for Defu Foodstuff Pte Ltd, 2016 SPRING SINGAPORE Innovation & Capability voucher for Superlative Foods, 2015 SPRING Singapore Innovation & Capability voucher for Defu Foodstuff Pte Ltd, 2013 Nanyang Polytechnic - Defu Foodstuff Pte Ltd Industry Collaboration, 2013 SPRING Singapore Innovation & Capability voucher for Antioxidant Centre Pte Ltd, 2013 BASF Newtrition Asia Research Grant, 2013 Nanyang Polytechnic Capability Development Project Grant, 2013 Singapore National Health & Medical Research Council, Exploratory/ Development Grant, 2012 Miss Claudine Loong Miss Claudine Loong is a lecturer at the School of Chemical & Life Sciences, Nanyang Polytechnic (NYP) Singapore. Prior to NYP, she worked as a Clinical Dietitian in restructured hospitals. Her area of specialization are Head and Neck Cancer, Eating Disorders, General Surgery, Weight Management and Geriatric Medicine. She had conducted multiple nutrition talks and developed Clinical Nutrition Management protocols and nutrition education materials. Relevant Publications: Tay ME, Ong SH, Ho XL, Tsen YT, Chu G, Loong C, Khaw R, Lee MKJ & Loke WM. Nutrient Deficiency Risk Assessment of Free-Living Older Adults in Singapore. Journal of Aging Research and Clinical Practise. 2016; accepted for publication.